Ordies S et al. Flow-controlled ventilation during EVLP improves oxygenation and preserves alveolar recruitment. Intensive Care Med Exp. 2020 Nov 25;8(1):70. doi: 10.1186/s40635-020-00360-w.

This randomized controlled study compared FCV to conventional VCV for ventilation of porcine lungs during ex vivo lung perfusion (EVLP). Fourteen porcine lungs were mounted on EVLP after a warm ischemic interval and ventilated for six hours with VCV or FCV, respectively. FCV led to improved oxygenation and alveolar recruitment, with a higher proportion of well-aerated lung tissue and less atelectatic areas. Thus, FCV is a potential strategy to prolong EVLP over time, with less risk of volutrauma and atelectrauma and thus less risk of ventilator induced lung injury (VILI).