Abram et al. Individualised flow-controlled versus pressure-controlled ventilation in a porcine oleic acid-induced acute respiratory distress syndrome model. Eur J Anaesth 2023

In experimental ARDS individualized FCV improved P/F ratio (+35%; P=0.07), while a lower minute volume (-29%; P=0.005) was required to obtain even lower PaCO2 levels (-20%; P=0.006) as compared to standard of care PCV in experimental (oleic acid induced) ARDS. This improved gas exchange may relate to the reduced pulmonary shunt fraction (-63%; P=0.008) that was observed. Hemodynamic stability was improved in the subjects ventilated by FCV evidenced by less noradrenaline (-70%; P=0.037) needed to maintain the mean arterial pressure >65 mmHg. These data, together with less mechanical power applied with FCV (-40%; P=0.001), underline the lung protective potential of FCV.